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Carol Heckman

Bowling Green State University

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Inputs coming into a cell by a signaling pathway are redirected in ways that are influenced by other signaling inputs.  This gives rise to a large number of cell states.  We have no rule book telling how the system works as a whole.  To get actionable information about such systems, we combine the knowledge of features having a clear relationship to physiology with results from drug treatment.  Our aim is to enable investigators to learn how the regulation of these features is relevant to drug development.